Dosage: Shake the Nobivac® Canine 1-Cv vial and transfer its contents to the Nobivac® Canine 1-DAPPv vial aseptically. Mix gently until dissolved. Use entire contents immediately after rehydration. Vaccinate with 1 ml subcutaneously or intramuscularly. The initial dose may be given at 6 weeks of age or older. Repeat at 2 to 4 week intervals until the dog is 12 weeks of age. A minimum of two doses is required for primary immunization. Annual revaccination with one dose is recommended. Warnings: Contains gentamicin as a preservatives Vaccinate only healthy, non-parasitized dogs Do not vaccinate pregnant bitches The use of a biological product may produce anaphylaxis and/or other inflammatory immune-mediated hypersensitivity reactions. Antidote: Epinephrine, corticosteroids, and antihistamines may all be indicated depending on the nature and severity of the reaction. The age at which material antibody for canine Parvovirus no longer interferes with the development of active immunity varies according to the bitch's titer and quantity of colostral antibodies absorbed by the puppy.